Giving some slack, it would be the 10MM Pistol.
If I had to name a weapon I 'liked' it'd be 'none' if I had to say it.
The only weapon that behaved normally as for put-put-putting enemies to sleep was a maximodded FuckYou RIfle (Assault) with maxed Semi-Auto and Sniper perks, and it's the ugliest thing I've ever seen and I worked at a butchery for a week. The animations and combat with them are incredibly annoying and stupid, Nate is afraid of blocking for more than some set frames and hits like a pussy with asma attacks. The Furious Power Fist, which is just a prefix with a broken buff and that bat with decreased AP cost. Melee/Unarmed: There's two weapons actually useful in each. Cool I guess, it'de be better if it was different from the laser versions. The Musket is a gimmick fired once and the Gatling Laser, good waste of ammo. There's a reskinned version and you can take off the stock. Energy Weapons has barely any perk (urgh) buffs and has the Laser Rifle. This, of course, applies to gear avaleible, subject of matter weapons. What it has, it's just other things staged or rearranged to seem unique. There's the thing: Fallout 4 has NOTHING to offer that other games haven't done already and better.